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Learn About Wet Age-related Macular Degeneration (wet AMD)

Wet AMD can make everyday living difficult and challenging. If you are currently being treated with an anti-VEGF medication, then there’s a new wet AMD treatment available for you. Learning about what’s happening in your eye can help you better understand how treatment works. 

How wet AMD affects the eye

While the exact cause of wet AMD is not known, it occurs when:

  • Blood vessels grow abnormally in the eye
  • The blood vessels leak fluid into a part of the eye called the macula
  • The macula swells, leading to blurred vision and vision loss

HEALTHY EYE

Healthy eye illustration

WET AMD EYE

Eye with wet AMD diagram illustration

Taking steps to help maintain your vision

SUSVIMO is a treatment option that can provide similar results as monthly injections* with as few as 2 treatments a year.  

Callout: If you're looking for a new treatment option, you should talk with a Retina Specialist and find out if SUSVIMO is right for you

*Ranibizumab.

What is SUSVIMO (ranibizumab injection)?

SUSVIMO (ranibizumab injection) is a prescription medicine used to treat adults with neovascular (wet) Age‑related Macular Degeneration (AMD) who have responded to at least two injections of a Vascular Endothelial Growth Factor (VEGF) inhibitor in the gel-like part of the eye (intravitreal). It is not known if SUSVIMO is safe and effective in children.

What is the most important information I should know about SUSVIMO?

SUSVIMO (ranibizumab injection) is delivered into the eye using the SUSVIMO implant. The SUSVIMO implant and the procedures to insert, fill, refill, and remove the eye (ocular) implant can cause serious side effects, including:

  • An eye infection (endophthalmitis). Endophthalmitis is an infection of the eyeball that can cause permanent damage to your eye, including blindness. Call your healthcare provider right away if you have increasing eye pain, vision loss, sensitivity to light, or redness in the white of the eye. Endophthalmitis requires urgent (same-day) medical or surgical treatment
  • A missing layer on top of the white part of the eye (conjunctival erosion). Conjunctival erosion is an area that becomes missing (defect) in the layer (conjunctiva) that covers the white part of the eye, which may result in exposure of the implant. Call your healthcare provider right away if you have a sudden feeling that something is in your eye, eye discharge, or watering of the eye. Conjunctival erosion may require surgical treatment
  • An opening of the layer that covers the white part of the eye (conjunctival retraction). Conjunctival retraction is an opening or gaping in the layer (conjunctiva) that covers the white part of the eye, which may cause the implant to be exposed. Call your healthcare provider right away if you have a sudden feeling that something is in your eye, eye discharge, or watering of the eye. Conjunctival retraction may require surgical treatment

Do not receive SUSVIMO if you:

  • Have an infection in or around your eye
  • Have active swelling around your eye that may include pain and redness
  • Are allergic to ranibizumab or any of the ingredients in SUSVIMO

Talk to your healthcare provider before receiving SUSVIMO if you have any of these conditions.

Before receiving SUSVIMO, tell your healthcare provider about all of your medical conditions, including if you: 

  • Are currently taking or have recently taken medicines that lower the chance of blood clots forming in the body, such as warfarin, low or regular doses of aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Are pregnant or plan to become pregnant. It is not known if SUSVIMO will harm your unborn baby. You should use birth control during your treatment with SUSVIMO and for 12 months after your last dose of SUSVIMO 
  • Are breastfeeding or plan to breastfeed. It is not known if SUSVIMO passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive SUSVIMO

Tell your healthcare provider about all the medicines you take, including prescription and over‑the‑counter medicines, vitamins, and herbal supplements.

What are other possible side effects of SUSVIMO?

The SUSVIMO implant and the procedures to insert, fill, refill, and remove the eye (ocular) implant can cause other serious side effects, including: 

  • Tear and separation of layers of the retina (rhegmatogenous retinal detachment). Rhegmatogenous retinal detachment is a tear and separation of one of the layers of the retina in the back of the eye that senses light. Call your healthcare provider or go to the emergency room right away if you see flashing lights, see a curtain or veil covering part of your vision, or have a change in, or a loss of vision. Rhegmatogenous retinal detachment requires surgical treatment
  • Implant movement (implant dislocation): Tell your healthcare provider right away if you notice that the implant has moved out of place. This movement may require surgical treatment to correct
  • Bleeding (vitreous hemorrhage): Vitreous hemorrhage is bleeding within the gel-like substance (vitreous) inside of your eye. Call your healthcare provider right away if you have an increase in moving spots or what looks like spider webs in your vision, as you may need an additional eye surgery
  • Bump on top of the white layer of the eye (conjunctival bleb): Conjunctival bleb is a small bulge in the layer (conjunctiva) that covers the white part of the eye where the implant is inserted. This may be due to leakage of fluid from the inside of the eye. Call your healthcare provider right away if you have a sudden feeling that something is in your eye (foreign body sensation), see a bulge over the white part of your eye, have eye discharge, or have watering in the eye. You may need medical or surgical treatment
  • Temporary decrease in vision after the SUSVIMO procedure

The most common side effects of SUSVIMO include: 

  • Blood on the white of the eye
  • Eye pain
  • Redness in the white of the eye
  • Sensitivity to light

These are not all the possible side effects of SUSVIMO. 

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects to Genentech at 1-888-835-2555. 

Please see Important Safety Information, including Serious Side Effects, as well as the SUSVIMO full Prescribing Information and Medication Guide.